This would indicate that most, if not all, of the studies using rd1-C3H mice as a model of retinal degeneration published within the past 65 years (since 1948) probably used the double mutants unknowingly and that the conclusions, based on the erroneous assumption that these mice are a simple model of photoreceptor degeneration, should be interpreted with caution. Here, PDE6B is linked to retinal degeneration.