In order to identify a subgroup of patients with poorer prognosis who most likely benefit from adjuvant chemotherapy, we selected localized chemo-naïve SS patients from our previously studied series [6] and assessed the prognostic role of CXCR4, IGF-1R and Ezrin by correlating their expression with clinical and histological parameters. The gene discussed is CXCR4; the disease is synovial sarcoma.