The overall findings of the first part of this study (schematically summarized in Figure 4) let us conclude that miR-17 deregulates a core RUNX1-miRNA mechanism of CBF-AML pathogenesis, since it recapitulates the same effects of both RUNX1-MTG8 and CBFB-MYH11 fusion proteins. This evidence concerns the gene RUNX1 and acute myeloid leukemia.