PSMB8 and non-small cell lung carcinoma: The activities of the β5 subunit of the constitutive proteasome and the LMP7 subunit of the immunoproteasome were significantly reduced in both the H1993 (NSCLC) and SHP77 (SCLC) cell lines when treated with the predetermined IC50 doses of CFZ for 48 hours (Figure 2).