Therefore, we studied the association between these five genetic variants associated with both obesity and obesity co-morbidities (IGF2BP2 rs4402960, LPL rs320, LPL rs328, KCJN rs5219, and MTHFR rs1801133) and elite athletic status in a relatively-large cohort (n = 929, from Poland and Russia) of sprint/power and endurance athletes. This evidence concerns the gene MTHFR and obesity disorder.