Table 2 shows variables associated with OS in univariate and multivariate Cox proportional hazard models. Univariate analysis revealed that age, ECOG PS, BMI, primary site, lymph node metastasis, visceral metastasis, therapies for UC, albumin, ALP, LDH, CRP, and SMI were associated with OS. Multivariate analysis showed that, in a reduced model, SMI was a significant predictor of shorter OS (hazard ratio (HR) 0.90, P <0.001), along with upper urinary tract cancer, lymph node metastasis, visceral metastasis, higher ALP, and higher CRP. The gene discussed is CRP; the disease is metastatic malignant neoplasm in the lymph nodes.