To clarify whether AAM were involved in the L. sigmodontis-mediated protection against an E. coli-induced sepsis, we used IL-4Rα/IL-5 double deficient BALB/c mice—which do not develop AAM [39], and IL-4-deficient BALB/c mice, which lack the suppressive effect of AAM [40]. The gene discussed is IL4; the disease is Sepsis.