Fig. 3 (B) shows ovarian cancer module 8, in which EGR1 positively regulates several genes (AQP1, BGN, CALB2, CEND1, COL1A1, COMP, HNT, IRX5, ITGA5 and ITGB1) and miRNAs (miR-214, miR-152, miR-199a and miR-199b) in the module at the same time. The gene discussed is IRX5; the disease is ovarian carcinoma.