AKT1 and cancer: For miRNAs, several articles support that miR-199a, miR-199b, miR-214, and miR-382 are involved in the TGF-beta signaling pathway [57–60], and that miR-22 regulates the AKT/PTEN pathway [50, 51], which is closely related to the TGF-beta signaling pathway in several cancers [50, 61].