PTEN and ovarian carcinoma: Evidence in the literature shows that the previously known ovarian cancer-related miRNAs miR-152, miR-22, and miR-214 are also related to enriched pathways in this module: miR-152 is involved in ECM-receptor-interaction [48, 49], and miR-22 and miR-214 regulate the AKT/PTEN pathway and the p53 signaling pathway [50, 51], which are highly related to the ECM-receptor, focal adhesion and proteolysis pathways [52–55].