Thus, we investigated the patterns of pro-inflammatory (T-1 and T-17: with reference to CD3+ T cells producing Th-1/Th-17 type cytokines) and anti-inflammatory/regulatory (IL-10) T cell cytokine production in individual granulomas following stimulation with peptides from Mtb-specific RD-1 encoded proteins ESAT-6 and CFP-10. Here, PDE6B is linked to Granuloma.