Recent studies have demonstrated that MET is overexpressed in a variety of cancer types, and this gene has been recognized as a key oncogene that promotes tumor growth, angiogenesis and metastasis.35, 36, 37 Several studies also have reported that overexpression of MET correlates with poor clinical outcome in patients with NPC.38, 39 Here, we found that silencing of MET significantly inhibited the viability, colony formation, migratory and invasive abilities of NPC cells. This evidence concerns the gene MET and neoplasm.