It has been proposed that voltage-dependent anion channel (VDAC) could be part of the PINK1/Parkin pathway.16, 17 As shown in Figure 5c, the presence of one mutant allele of porin (porink05123), the Drosophila homologous of VDAC, was sufficient to counteract PINK1-mediated rescue on the survival of HD flies. Here, VDAC1 is linked to Huntington disease.