Moreover, ubiquitination of Mfn by Parkin may account for its rapid removal from the mitochondria, therefore preventing damaged mitochondrial fragments to fuse back and corrupt healthy mitochondria.35, 36 However, in our study, silencing Mfn failed to ameliorate the survival of HD flies and abolished the beneficial effect of PINK1 on neuronal survival. Here, PRKN is linked to Huntington disease.