To determine if PINK1-mediated neuroprotective effect involves Parkin, we examined whether Drosophila parkin overexpression (parkinOE) alleviates HD phenotype in Drosophila. Unexpectedly, overexpressing Parkin failed to modify the life expectancy or the photoreceptor loss of flies expressing Httex1p Q93 under the control of the neuronal driver elav-GAL4 (Supplementary Figure S1). Here, PRKN is linked to Huntington disease.