DNM1L and Huntington disease: In agreement with this, reducing DRP1 activity protected cultured neurons expressing mHtt from axonal trafficking defects and cell death,6 and rescued motility defects in a Caenorhabditis elegans model of HD.22 More recently, a selective inhibitor of DRP1, P110-TAT, was shown to inhibit the pathology of HD mouse models.24 It was also reported that mHtt directly interacts with DRP1 and, thereby, increases DRP1 GTPase activity and its association with mitochondria.6, 23, 24 This may explain why we found that increasing DRP1 expression in our HD fly model exacerbates further the adult lethality.