NSD1 and breast carcinoma: In breast cancer, loss of NSD1 expression is associated with resistance to anti-estrogens.11 NF-κB has a significant role in anti-estrogen resistant growth of breast cancer cells and NF-κB inhibitors reverse anti-estrogen resistance, which may involve induction of NSD1.45, 46, 47 Restoration of NSD1 expression upon DMAPT treatment could also alter sensitivity to other therapies, because NSD1 is essential for BIM expression (Figure 5).