SETD2 and urinary bladder cancer: Analysis of the public database cBioportal revealed significant mutations/deletion of NSD1 and SETD2 in multiple cancers, including bladder cancer (www.cbioportal.org).40, 41 In The Cancer Genome Atlas (TCGA) bladder data set (n=127), 8% of cases showed deletions, amplification, and/or mutation of NSD1.