In one of the bladder cancer data set in gene expression omnibus (GEO),42 we observed significant reduction in NSD1 expression in non-muscle invasive urothelial cancer with or without carcinoma in situ and mucosa invasive carcinoma but not in carcinoma in situ compared with normal urothelium (Figure 6a). The gene discussed is NSD1; the disease is urinary bladder carcinoma.