In contrast, an increase of FOXO3a phosphorylation was observed in NB cells treated with shRNAs that simultaneously depleted BMCC1 (Figure 3b) with elevated AKT phosphorylation (Figure 2d), indicating that BMCC1 modulates FOXO3a activity by abrogating the phosphorylation of AKT. This evidence concerns the gene AKT1 and neuroblastoma.