TrkA-dependent apoptosis in neuronal cells is triggered by the depletion of NGF, resulted in spontaneous regression in NB.10, 11, 38 NGF depletion facilitates FOXO3a activity mediated by BIM through the negative regulation of PI3K-AKT signaling pathway.24 Therefore, BMCC1 may contribute to the spontaneous regression through AKT-FOXO3a regulation. This evidence concerns the gene PRUNE2 and neuroblastoma.