PRUNE2 and neuroblastoma: Phosphorylation-dependent inhibition of FOXO3a mediated by activated AKT promotes cell survival, and deregulation of this pathway strongly associates with poor prognosis of NB.23 Because BMCC1 expression is decreased in unfavorable NB,16 we investigated whether BMCC1 modulates proapoptotic FOXO3a activity when AKT activity was inhibited.