ANXA2 and pancreatic neoplasm: Mia-Paca2 cells exhibited the lowest levels of ANXA2 expression among several pancreatic cancer cell lines tested (Supplementary Figure S3); therefore, we constructed stable Mia-Paca2 human pancreatic carcinoma cell lines expressing wild-type or Y23A ANXA2 using a retroviral gene expression system (Supplementary Figure S4).