ANXA2 is a pleiotropic gene that functions in multiple pathways, including those involved in signal transduction, membrane fusion, cell adhesion, DNA synthesis, cell proliferation, and fibrinolysis.1, 2, 3 In cancer, ANXA2 is overexpressed in many types of tumors, including those arising in the breast, liver, prostate, and pancreas.4, 5 ANXA2 has important roles in cancer cell migration, adhesion, invasion, and metastasis. The gene discussed is ANXA2; the disease is cancer.