ANXA2 and familial pancreatic carcinoma: Expression of ANXA2 is upregulated in pancreatic cancer cell lines and primary pancreatic tumors.6, 7, 8 Furthermore, Akt/mTOR signaling is responsible, at least in part, for the upregulation of ANXA2 observed in recurrent pancreatic cancer following adjuvant therapy with gemcitabine.