CCNB1 and cancer: Anticancer insights derived from cell cycle research have given birth to the idea of cell cycle G2 checkpoint abrogation as a cancer-cell-specific therapy.38 The cyclin B1/Cdc2 complex, which is kept inactive by phosphorylation of Cdc2, has a key role in promoting the G2/M phase transition.39 At the onset of mitosis, Cdc25C, a dual specificity phosphatase, is activated for dephosphorylation of Cdc2.