These findings are complementary to a recent study of changes in translation brought about by eIF4A inhibition in a cultured T-cell acute lymphoblastic leukemia cell line.28 In that study, use of a non-specific eIF4A inhibitor in a cell line expressing high levels of eIF4A2 also led to translational downregulation of mRNAs enriched for G-quadruplex–forming sequences. Here, EIF4A1 is linked to acute lymphoblastic leukemia.