Indeed, angiotensin II exerts a potent role in the control of cardiovascular homeostasis through specific receptors, traditionally AT1R and AT2R. AT1R has demonstrated a crucial role in the diabetes/obesity enhanced response to angiotensin II [10] as well as in the pathogenesis of diabetic vascular dysfunction [16] and clinically on the basis of the therapeutic ability of angiotensin converting enzyme (ACE) inhibitors and AT1R blockers to decrease vascular complications in DM patients. Here, AGTR1 is linked to obesity due to melanocortin 4 receptor deficiency.