ACE and obesity due to melanocortin 4 receptor deficiency: Indeed, angiotensin II exerts a potent role in the control of cardiovascular homeostasis through specific receptors, traditionally AT1R and AT2R. AT1R has demonstrated a crucial role in the diabetes/obesity enhanced response to angiotensin II [10] as well as in the pathogenesis of diabetic vascular dysfunction [16] and clinically on the basis of the therapeutic ability of angiotensin converting enzyme (ACE) inhibitors and AT1R blockers to decrease vascular complications in DM patients.