HSP90B1 and neoplasm: Putative benefits of this latter form of a vaccine include the “off-the-shelf” utility (i.e., the vaccine may be used on essentially any patient and does not need to come from autologous tumor), the “host versus graft” immune cross-reactivity with the allogeneic cells, and the “continuous-release format” of the GRP94 as an advantage in stimulating immune responses in contrast to the bolus effect from an injectable vaccine.