Taking into consideration our previous findings on the enhanced secretion of EGF from peripheral immune cells of patients with relapsing-remitting MS [24] and the existence of CNS-infiltrating immune cells (mainly CD45+ cells) in the SVZ of EAE-induced mice already on day 3 after immunization [25], it can be assumed that the immune system contributes to the increased EGF levels within the SVZ and the consequent SVZ-derived NSC amplification and mobilization. This evidence concerns the gene PTPRC and relapsing-remitting multiple sclerosis.