This led to the American Heart Association (AHA/ASA) guidelines for intravenous tPA administration to be revised to increase the window of treatment from 3 hours to 4.5 hours given certain limitations and patient-specific criteria (patients with age >80, NIHSS > 25, previous stroke and diabetes, and anticoagulant use were excluded) [1, 34, 36]. The gene discussed is PLAT; the disease is Stroke.