PLAT and intracranial hemorrhage: The Antiplatelet Therapy in Combination with Recombinant tPA Thrombolysis in Ischemic Stroke (ARTIS) study showed that use of 300 mg intravenous acetyl salicylic acid within 1.5 hours of tPA did not improve outcome at 3 months and increased the rate of symptomatic intracranial haemorrhage [20, 37, 39].