Efficacy and safety of combined intravenous tPA and eptifibatide compared with intravenous tPA alone were investigated in the phase II Combined Approach to Lysis Utilizing Eptifibatide and Recombinant Tissue Plasminogen Activator in Acute Ischemic Stroke—Enhanced Regimen stroke trial (CLEAR-ER) study. The gene discussed is PLAT; the disease is Stroke.