At follow-up (longitudinal analyses), results demonstrate depressive symptoms to be significantly predictive of QoL measured by AcroQoL (p < 0.001) and SF-36 (p = 0.001) in acromegaly in a similar model with age, gender, disease duration, basal GH levels, tumor size, and possible treatment modalities and comorbidities as covariates. The gene discussed is GH1; the disease is neoplasm.