Taken together, with the emerging role played by the ECS in obesity and with over production of the AA-derived EC prolonging stimulation of CB1 that leads to dysregulation (Matias et al., 2006, 2008), there is convincing evidence to focus future research on dietary PUFA and the ECS in metabolic syndrome. Here, CNR1 is linked to obesity due to melanocortin 4 receptor deficiency.