More recently, using a human mutant rhodopsin allele [proline-to-histidine change at codon 23 (P23H) rhodopsin] which induces mislocalization and degradation of the human protein, the research group generated a knock-in mouse line which modeled a common cause of autosomal dominant retinitis pigmentosa (Price et al., 2011). This evidence concerns the gene RHO and autosomal dominant retinitis pigmentosa.