ATXN8 and nervous system disorder: The KLHL1 gene locus lies near genes implicated in Spinocerebellar ataxia type 8 (SCA8; Ikeda et al., 2007), a rare and slowly progressive neurological disease characterized by the presence of trinucleotide expansions in two genes: ataxin 8 (ATXN8) and ATXN8 opposite strand (ATXN8OS).