PPARGC1A and cerebellar ataxia: Of note, the kinematic ataxia phenotype observed in PGC-1α−/− mice (Figure 1) closely resembles the gait abnormalities reported in rodent models of both Huntington (Vandeputte et al., 2010) and Parkinson (Vlamings et al., 2007; Chuang et al., 2010) Diseases.