PPARGC1A and cerebellar ataxia: Given the high expression of PGC-1α in the cerebellum compared to other brain regions (Cowell et al., 2007), we hypothesized that motor impairment in PGC-1α−/− animals would include ataxia and conducted CatWalk gait analyses on male PGC-1α+/+ and −/− littermates at 6 months of age.