PPARGC1A and nervous system disorder: CatWalk gait analyses have been validated as indicators of motor abnormalities in rodents, and several CatWalk variables indicating paw print dimensions and the time and distance relationships between footfalls are affected in rodent models of neurological diseases in which PGC-1α has been implicated, such as Huntington (Vandeputte et al., 2010) and Parkinson (Vlamings et al., 2007; Chuang et al., 2010) Diseases.