AGT and ischemia: In patients with SCI, it is possible that hyperreactivity of the cutaneous vasculature to Ang II contributes to both the reduction in ischemia-induced vasodilation that occurs following removal of a pressure stimulus applied to skin (Schubert and Fagrell, 1991) and to impairing axon reflex-evoked vasodilation in skin (Kuesgen et al., 2002).