The multivariate logistic regression of the ERCs cohort revealed that CD8 (OR 0.996; 95% CI 0.994–0.998; P = 0.025) adds predictive information for lymph node involvement independently of tumor vascular invasion (OR 1.465; 95% CI 1.319–1.628; P = 0.0005) and tumor border configuration (OR 1.254; 95% CI 1.169–1.344; P = 0.001, Table 3). Here, CD8A is linked to neoplasm.