To explore relationships occurring between tumor infiltration by cells of the adaptive immune system and lymph node involvement, distribution of T-cell markers such as CD3, CD4, CD8, CD45RO, PD-L1, HLA class II, TIA-1, FoxP3, and IL-17 was comparatively evaluated in nodal negative and nodal positive tumors. This evidence concerns the gene FOXP3 and neoplasm.