In recent years, it has become apparent that the SDF-1α/CXCR4 biological axis is a critical mediator of tumor–stromal interactions and is closely related to the malignant process and poor prognosis in a variety of epithelial cancers, such as pancreatic cancer, liver cancer, lung cancer, breast cancer, and prostate cancer [15-19]. Here, CXCL12 is linked to familial pancreatic carcinoma.