The SDF-1α/CXCR4 biological axis can activate multiple intracellular signaling pathways, including the FAK, AKT, ERK1/2, P38, STAT3, mTOR, and Wnt/β-catenin signaling pathways in various cancers [24, 35, 46, 47]. This evidence concerns the gene CXCR4 and cancer.