CXCR4 and neoplasm: NSCLC patients with high infiltration rates of TIA-1+ or IFN-γ+ cells had a better prognosis than those with low infiltration rates.(Table 2) After adjusting for sex, tumor differentiation, tumor size, lymph node metastasis, TNM stage, and expression of B7-H1, B7-H3, TIA-1+, IFN-γ+, and CXCR4, patients whose tumors were positive for B7-H1 (HR, 1.90; 95% CI, 1.09-3.30; p=0.02) or B7-H3 (HR, 2.26; 95% CI, 1.21-4.23; p=0.01) were at an increased risk of death.