EPHA5 and Familial prostate cancer: Representative examples displaying positive EphA5 protein immunostaining in a noncancerous prostate sample, weak EphA5 protein immunostaining in a low-grade prostate cancer specimen (Gleason score = 7) and negative EphA5 protein immunostaining in a high-grade prostate carcinoma sample (Gleason score = 9) are shown in Figure 5.