Similarly to previous studies, EphA5 gene hypermethylation was also detected in all 6 PCa cell lines and in 71.1% of tumor samples, whereas only 12.8% of benign prostatic hyperplasia and 8.7% of paired noncancerous tissues exhibited hypermethylation of the EphA5 gene within the same CpG islands as the study on breast tumor. This evidence concerns the gene EPHA5 and benign prostatic hyperplasia.