TBX1 and chordoma: Or perhaps, given the rarity of chordomas relative to BNCTs, all BNCTs have the potential to transform into chordoma under the right circumstances, such as an environmental insult or chromosomal alteration; recent studies have implicated gene amplification and duplication in chordoma development, with attention focused on Sonic hedgehog and T (brachyury) genes [15,20,21,23,26].