In order to characterize novel agents and molecular pathways able to regulate the expression of NK cell activating ligands in MM cells, we investigated the activity of nitric oxide donors [DETA-NO and the NO-releasing pro-drugs NCX4040 (NO-aspirin) and JS-K] on the expression of the CD155/PVR, an activating DNAM-1 ligand regulated by DDR and reactive radicals in different models [23,24]. The gene discussed is CD226; the disease is Miyoshi myopathy.