As our laboratory has recently shown that genotoxic drugs (e.g. melphalan or doxorubicin) can trigger the expression of NK activating ligands on MM cells in an ATM/ATR/Chk1/2-dependent and p53-independent manner [12,24], we investigated the possibility that a similar mechanism might be involved in the presence of NO donors. Here, CHEK1 is linked to Miyoshi myopathy.