XRCC2 and neoplasm: Accepting this caveat the mutational rate for this tumour was 0.49 Mb−1, a rate comparable to the overall cohort, and of the 18 SNVs identified in this patient (see Supplementary Table 1), a mutation in gene XRCC2 (c.6T>Gp.Cys2Trp) is of particular note.