Moreover, we demonstrated that miR-146a downregulation in HCC cells led to the upregulation of VEGF via 2 signaling pathways: 1) the repression of APC expression, leading to β-catenin accumulation in nucleus, and 2) a direct reduction in HAb18G expression, which consequently promoted the expression of NF-κB p65. This evidence concerns the gene VEGFA and hepatocellular carcinoma.