Marfan’s syndrome and Loeys-Dietz syndrome represent rare congenital connective tissue disorders that have similar patterns of cardiovascular defects (e.g., thoracic aortic aneurysm); these syndromes are caused by mutations in the genes encoding for TGF-β2 or TGF-β receptor (TGFBR) I or II [34-36]. The gene discussed is TGFB2; the disease is connective tissue disorder.