LEF1 and sebaceous gland neoplasm: Particularly, treatment of mice expressing mutant Lef1 in the basal compartment of the epidermis (K14+) (K14ΔNLef1 mice) with a single sub-threshold dose of the carcinogen DMBA (150 nM, 7,12-dimethylbenz(a)anthracene) induced the formation of sebaceous tumours in high frequency in a spatially and temporally controlled manner (Fig. 1a–c and Supplementary Fig. 1a–c).