Recently, many tumor markers such as SCCA, CEA, CA19-9, MMP-9, IL-6, CYFRA 21–1, DKK-1, M-CSF, MiR-18a, MiR-1246 and many other genes were evaluated for ESCC diagnosis [3, 27–30]. The gene discussed is CEACAM5; the disease is esophageal squamous cell carcinoma.