Of these lncRNAs, as shown in Figure 2A-C, the levels of POU3F3 (p < 0.001), HNF1A-AS1 (p < 0.001) and SPRY4-IT1 (p < 0.001) were significantly higher in ESCC patients comparing with normal controls. This evidence concerns the gene POU3F3 and esophageal squamous cell carcinoma.