The protective effects of AK7 in MPTP mouse model of PD are less expected, since this neurotoxin interferes with mitochondrial complex I. AK7 shows high in vitro selectivity for SIRT2, and accordingly increases α-tubulin acetylation (used here as a pharmacodynamic marker for compound activity in vivo) in the striatum of MPTP treated mice. Here, SIRT2 is linked to Parkinson disease.