CD8A and neoplasm: Thus, MDSCs play a central role in the development of immunosuppressive tumor microenvironment [43], as also emphasized by the fact that functionally active tumor-specific CD8+ T-cells can develop anergy or undergo apoptosis when adoptively transferred into a microenvironment containing MDSCs; moreover, depletion of MDSCs restore CD8+ T cell function, thus confirming their role in induction and maintenance of host immunosuppression [41].