Similarities of POEMS with ROSA26.vFLIP;Cdh5(PAC).creERT2 TG mice included: i) neuropathic symptoms, which in mice are likely related to hyperplasia of the perineurium around nerve bundles in spinal nerve roots, ganglion and skeletal muscle, ii) systemic presence of elongated endothelial cells, particularly in the heart, which is also increased in size, reminiscent of organomegaly seen in POEMS iii) proneness to develop endocrinopathy (e.g., diabetes), as suggested by increased glycemic levels observed in TG mice, and iv) overproduction of proinflammatory cytokines, including TNFα, IL10, IL6. Here, IL6 is linked to endocrine system disorder.