Moreover, vFLIP transcriptome, as defined by in vitro gene expression profiling of both vFLIP-expressing endothelial cells and PEL [28,40], highlights the fact that vFLIP activates several proinflammatory cytokines directly implicated in tumor microenvironment and remodeling of myeloid cells, particularly IL4, IL10, IL6, IL13, TGFβ, CCL5/RANTES,IL2, IL1β, G-CSF, similar to those seen in our in vivo data. This evidence concerns the gene CSF3 and neoplasm.