ITGA2B and Glanzmann thrombasthenia: In this study we generated a patient-specific hiPSC-based model of Glanzmann thrombasthenia with compound heterozygosity of 2 novel mutations in the ITGA2B gene, which enabled the perpetual in vitro differentiation of GPIIbIIIa deficient platelets and MKs from hematopoietic precursors.