Using targets suggested by the literature, we performed treatment time courses for PDGF, S1P, and rosiglitazone (RZN), an agonist of PPARγ, in SSc and normal dermal fibroblasts to assess the role of each signaling pathway is SSc pathogenesis; we performed two additional time courses each for IL-4 and IL-13 to expand upon the work of Greenblatt et al. [4]. Here, IL13 is linked to systemic sclerosis.