In the present study, we collected paired pNPC and rNPC samples from 45 individuals from two institutions and compared the expression of Jab1/Csn5 (nuclear and cytoplasmic), phosphor-Stat3 (p-Stat3) (Tyr705), Akt (nuclear and cytoplasmic), CHOP, Ki-67, and terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end-labeling (TUNEL) in the paired tumor tissues. The gene discussed is STAT3; the disease is neoplasm.