HSPA5 and cancer: HDAC class I and II inhibitors trichostatin-A and suberoylanilide hydroxamic acid combined with RGD4C-AAVP carrying CMV or Grp78 promoter reactivated RGD4C-AAVP/CMV efficacy and enhanced RGD4C-AAVP/Grp78 in cancer cells specifically, respectively.