Interestingly, however, at an older age (4 months old), the Tbk1-TKO mice had splenomegaly and higher splenocyte numbers (Fig. 2a) as well as increased numbers of CD4+ and CD8+ T cells in different lymphoid organs and the peripheral blood (Supplementary Fig. 1e). This evidence concerns the gene TBK1 and Splenomegaly.