A caveat is that sgp130 also regulates the IL-6-related cytokines leukemia inhibiting factor and oncostatin M, but sgp130 has a lower affinity for leukemia inhibiting factor and oncostatin M than for the IL-6-sIL-6R complex, and it prevents mainly trans-signaling by IL-6-sIL-6R complexes [30]. The gene discussed is IL6; the disease is leukemia.