IL-1α and TNF-α induction of Adamts5 was found to occur predominately in synovium and the patellar but not in femoral head or tibial joint cartilage in ex vivo mouse joints, indicating that ADAMTS5 may not be the predominant aggrecanase in articular cartilage in arthritis but in fact may affect cartilage indirectly [37]. This evidence concerns the gene ADAMTS5 and arthritic joint disease.