This function should be considered in assigning a role for this DUB in breast cancer because many breast tumors, particularly those with triple-negative status, have mutations in p53. USP10 also antagonizes c-myc transcription through deubiquitination of SIRT6, a histone deacetylase, and NF-κB signaling through deubiquitination of NEMO [52]. The gene discussed is USP10; the disease is breast cancer.