The first study simultaneously investigating PET, MRI, and US in patients with RA showed that changes in SUVs in RA-affected knees after initiation of anti-TNF therapy were also correlated with changes in MRI parameters and serum CRP and metalloproteinase-3 levels but not with changes in synovial thickness as measured via US [51]. The gene discussed is TNF; the disease is rheumatoid arthritis.