Kudo et al. and Yasui et al. have revealed that reduced human organic anion transporter 2 (hOAT2[SLC22A7]) transporter expression in the liver indicates a significant risk for HCC development in patients with chronic hepatitis C (Kudo et al., 2013, Yasui et al., 2014). The gene discussed is SLC22A7; the disease is hepatocellular carcinoma.