Notably, the auxiliary protein Uhrf1 found in the ‘darkorange’ module has previously been shown to interact with PRC2 members Ezh2 and Suz12 in prostate cancer cells, where elevated UHRF1 levels correlate positively with an increase in EZH2 and were associated with poor clinical outcome (51). The gene discussed is EZH2; the disease is Familial prostate cancer.